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投稿信
Dear Editor, We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience. The further information about the paper is in the following: GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease. We also confirm that this paper has not been published elsewhere nor has been submitted for publication elsewhere. Thank you for your consideration. Sincerely yours Jason Liu

Address:

Department of Faculty of Light and Chemical, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P.R.China

E-mail: Tel: Fax:

XXXXX@mail.gdut.edu.cn 86-551-36XXXXX 86-551-36XXXXX

求职信
April 20, 2011 P.O. Box 3 GDUT University Guangzhou, Guangdong, 510006 The People’s Republic of China Dear Sir/Madame, Your advertisement for a Network Maintenance Engineer in the April 10 Student Daily interested me because the position that you described sounds exactly like the kind of job I am seeking. According to the advertisement, your position requires a good university degree Bachelor or above in Computer Science or equivalent field and proficient in Windows NT 4.0and Linux System. I feel that I am competent to meet the requirements. I will be graduating from GDUT University this year with a MSC. My studies have included courses in computer control and management and I designed a control simulation system developed with Microsoft Visual and SQL Server. During my education, I have grasped the principles of my major subject area and gained practical skills. Not only have I passed CET - 6, but more importantly I can communicate fluently in English. My ability to write and speak English is a good standard. I would welcome an opportunity to attend you for an interview. Enclosed is my resume and if there is any additional information you require, please contact me. Sincerely yours Jason Liu


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