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Association of polymorphisms in glutathione S-transferase genes


A s i a n   J o u r n a l   o f   A n d r o l o g y( 2 01   5 )1   7 . 4 81 — 4 8 6   @2 01 5   A J A. SI MM &S J TU. Al l   r i g h t s   r e s e r v e d   1 0 0 8 — 6 8 2 X   w w w . a s i a a n d r o . c o m; w w w   a j a n d   r o l o g y   c o m   Op e nAc c e s s   ORI G   I NAL   AR TI CL E   A s s o c   i a t i o n   o f   p o l y mo r p h   i s ms   i   n   g l   u t a t h   i o n e   S — t r a n s f e r a s e   g e n e s( GS   1 , G ST T 1 , GST P1 ) wi t h   i di o p a t hi c   a z o o s p e r mi a   o r   o l i g o s p e r mi a   i n   Si c hu a n,   Ch i n a   Da ? Ke   Xi o n g   '   ’   ,   , Ho n g - Ha n   Ch e n   ,   '   '   , Xi a n — P i n g   Di n g   ’   '   , S h a o — Ho n g   Z h a n g   '   ’ 。 , J i a n - Hu i   Z h a n g   ,   ,   Th e   r e p o r t e d   e fe c t s   o f   t h e   g l u t a t h i o n e   S . t r a n s f e r a s e( GS T s ) g e n e s( GST MI _ . GS丌 I 。 a n d   GST P】 ) o n   ma l e   f a c t o r   i n f e r t i l i t y   h a v e   b e e n   i n c o n s i s t e n t   a n d   e v e n   c o n t r a di c t o r y . He r e . we   c o n du c t e d   a   c a s e . c o n t r o I   s t u d y   t o   i n v e s t i g a t e   t h e   a s s o c i a t i o n   b e t we e n   f u n c t i o n a l l y   i mp o ta r n t   p o l y mo r p h i s ms   i n   GS T   g e n e s   a n d   i d i o p a t hi c   ma l e   i n f e ti r l i t y 。 Th e   s t u d y   g r o u p   c o n s i s t e d   o f   3 61   me n   wi t h   i d i o p a t h i c   a z o o s

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