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Association of polymorphisms in glutathione S-transferase genes_论文

A s i a n   J o u r n a l   o f   A n d r o l o g y( 2 01   5 )1   7 . 4 81 — 4 8 6   @2 01 5   A J A. SI MM &S J TU. Al l   r i g h t s   r e s e r v e d   1 0 0 8 — 6 8 2 X   w w w . a s i a a n d r o . c o m; w w w   a j a n d   r o l o g y   c o m   Op e nAc c e s s   ORI G   I NAL   AR TI CL E   A s s o c   i a t i o n   o f   p o l y mo r p h   i s ms   i   n   g l   u t a t h   i o n e   S — t r a n s f e r a s e   g e n e s( GS   1 , G ST T 1 , GST P1 ) wi t h   i di o p a t hi c   a z o o s p e r mi a   o r   o l i g o s p e r mi a   i n   Si c hu a n,   Ch i n a   Da ? Ke   Xi o n g   '   ’   ,   , Ho n g - Ha n   Ch e n   ,   '   '   , Xi a n — P i n g   Di n g   ’   '   , S h a o — Ho n g   Z h a n g   '   ’ 。 , J i a n - Hu i   Z h a n g   ,   ,   Th e   r e p o r t e d   e fe c t s   o f   t h e   g l u t a t h i o n e   S . t r a n s f e r a s e( GS T s ) g e n e s( GST MI _ . GS丌 I 。 a n d   GST P】 ) o n   ma l e   f a c t o r   i n f e r t i l i t y   h a v e   b e e n   i n c o n s i s t e n t   a n d   e v e n   c o n t r a di c t o r y . He r e . we   c o n du c t e d   a   c a s e . c o n t r o I   s t u d y   t o   i n v e s t i g a t e   t h e   a s s o c i a t i o n   b e t we e n   f u n c t i o n a l l y   i mp o ta r n t   p o l y mo r p h i s ms   i n   GS T   g e n e s   a n d   i d i o p a t hi c   ma l e   i n f e ti r l i t y 。 Th e   s t u d y   g r o u p   c o n s i s t e d   o f   3 61   me n   wi t h   i d i o p a t h i c   a z o o s p e r mi a 。1   1 8   me n   wi t h   i d i o p a t h i c   o l i g o s p e r mi a .a n d   2 34   a g e - ma t c h e d   h e a l t h y   f e tl r i e   ma l e   c o n t r o l s .Ge n o mi c   DNA  wa s   e x t r a c t e d   f r o m  t h e   p er i p h e r a l   b l o o d 。a n d   a n al y z e d   b y   p o l y me r a s e   c h a i n   r e a c t i o n   a n d   r e s t r i c t i o n   f r a g me n t   l e n  h   p o l y mo r p h i s m  a n a l y s i s . T h e r e   w a s   a   s i g n i f i c a n t   a s s o c i a t i o n   b e t w e e n   t h e   G S   J   v a r i a n t   g e n o t y p e( 1 l e Na I +V a l Na 1 ) wi t h   i d i o p a t h i c   i n f e t r i l i t y   r i s k( o d d s   r a t i o【 0刚 : 1 . 5 3 ; 9 5 %c o n f i d e n c e   i n t e wa I [ e l l : 1 . 1 1 - 2 . 1 1 : P=0 . 0 0 9 ) . S i mi l a r l y , a   h i g h e r   r i s k   o f   i n f e t r i l i t y   w a s   n o t e d   i n   i n d i v i d u a l s   c a r yi r n g   a   g e n o t y p e   c o mb i n a t i o n  

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